Cirrhosis is a chronic, progressive and irreversible disease of the liver. It has a number of different causes:
In South Africa, the most common cause of cirrhosis is chronic alcoholism. Alcoholic liver disease develops after more than a decade of heavy drinking (a factor which varies between individuals).
Chronic hepatitis B, C and D are other causes. Hepatitis B is the most common cause of cirrhosis worldwide and, like hepatitis C, causes inflammation of the liver. Hepatitis D also affects the liver, but mostly in people who already have hepatitis B.
Autoimmune hepatitis occurs when the immune system attacks the liver. Inherited diseases such as Wilson disease can also affect the way the liver works.
Other lesser causes include:
1.non-alcoholic steatohepatitis, which is associated with diabetes;
2.blocked bile ducts, often caused by primary billary cirrhosis in which the ducts become inflamed, blocked and scarred;
3.drugs, toxins and infections (e.g. severe reactions to prescription drugs, prolonged exposure to environmental toxins, or parasitic infection such as bilharzia); and
4.repeated heart failure accompanied by liver congestion.read more
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